THE EFFECTS OF AQUEOUS EXTRACT FROM Khaya senegalensis ON THE HISTOLOGY OF LIVER AND KIDNEY OF ALBINO RATS

Abstract
Lasisi, E.M. Octoder 2008.
The stem bark of Khaya senegalensis was extracted and administered using aqueous method with the aim determining the effect of Khaya senegalensis (300mg/kg body weight) on liver and kidney of white albino rats. Experimental animals were randomly divided into 7groups with each group consisting of 5rats. Group 7 consists of the control and was orally administered with distilled water. Group 1, 2,3,4,5 and 6 consist of test animal received 300mg/kg dosage of the extracts on repeated basis for different numbers of days for 25days.
The result obtained from the study suggested that prolonged oral administration of aqueous extract from stem bark of Khaya senegalensis showed significant changes on the histology of liver and kidney of white albino rats.

Introduction

Histopathology derive from the word histo and pathology.
Histo means tissues while pathology indicates disease processes or changes.
Before tissues are processed, they are pre-fixed in chemicals called fixatives. The specimens are sent in fixatives to the laboratory where they are registered and given histology number. This number is the laboratory number used for the processing of the specimen.
Registered samples are transfered to the cut-up room for selection. Once part of the tissues are selected depending on the pathology presented, they are capped in tissue cassettes and transfered to the alcohol bath for processing starting from dehydration.